Hurko, O. : rechercher sur Z-Library

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1

Drug development for CNS disorders: strategies for balancing risk and reducing attrition

Pangalos, Menelas N., Schechter, Lee E., Hurko, Orest

Journal:

Nature Reviews Drug Discovery

Année:

2007

Langue:

english

Fichier:

PDF, 620 KB

english, 2007

2

Immunocytochemical analysis of fibre type differentiation in developing skeletal muscle

Stephen E. Moore, Orest Hurko, Frank S. Walsh

Journal:

Journal of Neuroimmunology

Année:

1985

Langue:

english

Fichier:

PDF, 16.76 MB

english, 1985

3

Marked Replicative Advantage of Human mtDNA Carrying a Point Mutation that Causes the MELAS Encephalomyopathy

Makoto Yoneda, Anne Chomyn, Andrea Martinuzzi, Orest Hurko and Giuseppe Attardi

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1992

4

Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): Phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3

Bellus, Gary A., Bamshad, Michael J., Przylepa, Kelly A., Dorst, John, Lee, Roland R., Hurko, Orest, Jabs, Ethylin W., Curry, Cynthia J.R., Wilcox, William R., Lachman, Ralph S., Rimoin, David L., Fra

Journal:

American Journal of Medical Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 843 KB

english, 1999

5

Abnormal fatty acid metabolism in childhood spinal muscular atrophy

Thomas O. Crawford, John T. Sladky, Orest Hurko, Anne Besner-Johnston, Richard I. Kelley

Journal:

Annals of Neurology

Année:

1999

Langue:

english

Fichier:

PDF, 155 KB

english, 1999

6

Prenatal diagnosis of Charcot-Marie-Tooth disease type 1a by multicolor in situ hybridization

Roger V. Lebo, Lucia Martelli, Ying Su, Lanying Li, Eric Lynch, Elaine Mansfield, Kong-Hu Pua, Daniel F. Watson, Jane Chueh, Orest Hurko

Journal:

American Journal of Medical Genetics Part A

Année:

1993

Langue:

english

Fichier:

PDF, 947 KB

english, 1993

7

Transfection of human skeletal muscle cells with SV40 large T antigen gene coupled to a metallothionein promoter

Dr Orest Hurko, Linda McKee, Judith G. E. M. Zuurveld

Journal:

Annals of Neurology

Année:

1986

Langue:

english

Fichier:

PDF, 2.13 MB

english, 1986

8

Phosphorus magnetic resonance spectroscopy of patients with mitochondrial cytopathies demonstrates decreased levels of brain phosphocreatine

S. M. Eleff, P. B. Barker, S. J. Blackband, J. C. Chatham, N. W. Lutz, D. R. Johns, R. N. Bryan, O. Hurko

Journal:

Annals of Neurology

Année:

1990

Langue:

english

Fichier:

PDF, 522 KB

english, 1990

9

Reply

Scott M. Eleff, Peter B. Barker, Steven J. Blackband, John C. Chatham, R. Nick Bryan, Orest Hurko

Journal:

Annals of Neurology

Année:

1990

Langue:

english

Fichier:

PDF, 130 KB

english, 1990

10

Mitochondrial DNA mutations in Leber's optic neuropathy

Journal:

Annals of Neurology

Année:

1994

Langue:

english

Fichier:

PDF, 122 KB

english, 1994

11

Recent advances in heritable ataxias

Journal:

Annals of Neurology

Année:

1997

Langue:

english

Fichier:

PDF, 287 KB

english, 1997

12

Translational medicine perspective in development of disease modifying therapies for Alzheimer's disease: biomarkers to buy down the risk

Hong I. Wan, Orest Hurko, Mark Day, J. Lynn Rutkowski

Journal:

Drug Development Research

Année:

2009

Langue:

english

Fichier:

PDF, 117 KB

english, 2009

13

Linkage mapping of the spinal muscular atrophy gene

Arthur H. M. Burghes, Susan E. Ingraham, Zsofia Kóte-Jarai, Scott Rosenfeld, Nancy Herta, Nitin Nadkarni, Christine J. DiDonato, John Carpten, Orest Hurko, Julaine Florence, Richard T. Moxley, Jan M.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 741 KB

english, 1994

14

The effects of 6-hydroxydopamine pretreatment on the accumulation of dopa and dopamine in brain and peripheral organs following l-dopa administration

L. D. Lytle, O. Hurko, J. A. Romero, K. Cottman, D. Leehey, R. J. Wurtman

Journal:

Journal of Neural Transmission

Année:

1972

Langue:

english

Fichier:

PDF, 517 KB

english, 1972

15

Mitochondrial DNA and leukoencephalopathies

Journal:

Molecular and Chemical Neuropathology (Neurochemical Pathology)

Année:

1996

Langue:

english

Fichier:

PDF, 394 KB

english, 1996

16

The Uses of Biomarkers in Drug Development

Journal:

Annals of the New York Academy of Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 123 KB

english, 2009

17

10.1038/88839

McGinnis, Ralph E., Fox, Helen, Yates, Phil, Cameron, Lee-Ann, Barnes, Michael R., Gray, Ian C., Spurr, Nigel K., Hurko, Orest, St. Clair, David

Journal:

Nature Genetics

Année:

2001

Langue:

english

Fichier:

PDF, 35 KB

english, 2001

18

Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke

Chavez, Juan C, Zaleska, Margaret M, Wang, Xinkang, Wood, Andrew, Hurko, Orest, Pangalos, Menelas N, Feuerstein, Giora Z

Journal:

Journal of Cerebral Blood Flow and Metabolism

Année:

2008

Langue:

english

Fichier:

PDF, 65 KB

english, 2008

19

Valuation of biomarkers

Hurko, Orest, Jones, Graham K.

Journal:

Nature Reviews Drug Discovery

Année:

2011

Langue:

english

Fichier:

PDF, 240 KB

english, 2011

20

Debriefing as a Strategic Tool for Performance Improvement

Nancy Corbett, Patricia Hurko, John T. Vallee

Journal:

Journal of Obstetric, Gynecologic, & Neonatal Nursing

Année:

2012

Langue:

english

Fichier:

PDF, 631 KB

english, 2012

21

Yeast kar1 Mutants Provide an Effective Method for YAC Transfer to New Hosts

F. Spencer, Y. Hugerat, G. Simchen, O. Hurko, C. Connelly, P. Hieter

Journal:

Année:

1994

Fichier:

PDF, 594 KB

1994

22

Specific [3H]quinuclidinyl benzilate binding activity in Digitonin-solubilized preparations from bovine brain

Journal:

Archives of Biochemistry and Biophysics

Année:

1978

Langue:

english

Fichier:

PDF, 1.17 MB

english, 1978

23

Future drug discovery and development

Journal:

Molecular Genetics and Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 159 KB

english, 2010

24

Sleep-disordered breathing in children with achondroplasia

Peter J. Mogayzel Jr., John L. Carroll, Gerald M. Loughlin, Orest Hurko, Clair A. Francomano, Carole L. Marcus

Journal:

The Journal of Pediatrics

Année:

1998

Langue:

english

Fichier:

PDF, 131 KB

english, 1998

25

Kearns-Sayre syndrome with features of Pearson's marrow-pancreas syndrome and a novel 2905-base pair mitochondrial DNA deletion

Mark W Becher, Marcia L Wills, Walter W Noll, Orest Hurko, Donald L Price

Journal:

Human Pathology

Année:

1999

Langue:

english

Fichier:

PDF, 4.15 MB

english, 1999

26

Translational Research in Central Nervous System Drug Discovery

Orest Hurko, John L. Ryan

Journal:

Neurotherapeutics

Année:

2005

Langue:

english

Fichier:

PDF, 114 KB

english, 2005

27

Target-based drug discovery, genetic diseases, and biologics

Journal:

Neurochemistry International

Année:

2012

Langue:

english

Fichier:

PDF, 191 KB

english, 2012

28

Novel antigens at the neuromuscular junction

Stephen E. Moore, Orest Hurko, Frank S. Walsh

Journal:

Journal of Neuroimmunology

Année:

1986

Langue:

english

Fichier:

PDF, 841 KB

english, 1986

29

The ADNI Publication Policy: Commensurate recognition of critical contributors who are not authors

Orest Hurko, Sandra E. Black, Rachelle Doody, P. Murali Doraiswamy, Anthony Gamst, Jeffrey Kaye, Thomas O. Obisesan, Henry Rusinek, Doug Scharre, Reisa Sperling, Michael W. Weiner, Robert C. Green

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 190 KB

english, 2012

30

Cervicomedullary compression in young patients with achondroplasia: Value of comprehensive neurologic and respiratory evaluation

Cheryl S. Reid, Reed E. Pyeritz, Steven E. Kopits, Bernard L. Maria, Henry Wang, Robert W. McPherson, Orest Hurko, John A. Phillips III, Arthur E. Rosenbaum

Journal:

The Journal of Pediatrics

Année:

1987

Langue:

english

Fichier:

PDF, 2.46 MB

english, 1987

31

Novel drug development for amyotrophic lateral sclerosis

Orest Hurko, Frank S. Walsh

Journal:

Journal of the Neurological Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 232 KB

english, 2000

32

Genetics and genomics in neuropsychopharmacology: the impact on drug discovery and development

Journal:

European Neuropsychopharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 351 KB

english, 2001

33

Drug Development for Rare Mitochondrial Disorders

Journal:

Neurotherapeutics

Année:

2013

Langue:

english

Fichier:

PDF, 349 KB

english, 2013

34

Preferential amplification and molecular characterization of junction sequences of a pathogenetic deletion in human mitochondrial DNA

Johns, Donald R., Hurko, Orest

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 1.17 MB

english, 1989

35

Mitochondrial leucine tRNA mutation in neurological diseases

Johns, DonaldR., Hurko, Orest

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 325 KB

english, 1991

36

IDENTICAL MITOCHONDRIAL DNA DELETION IN BLOOD AND MUSCLE

Johns, DonaldR., Drachman, DanielB., Hurko, Orest

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 324 KB

english, 1989

37

Directly Repeated Sequences Associated with Pathogenic Mitochondrial DNA Deletions

Donald R. Johns, S. Lane Rutledge, O. Colin Stine and Orest Hurko

Journal:

Proceedings of the National Academy of Sciences

Année:

1989

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1989

38

The impact of preclinical drug safety on R&D productivity

Journal:

Expert Opinion on Drug Discovery

Année:

2006

Langue:

english

Fichier:

PDF, 133 KB

english, 2006

39

Importance and hurdles to drug discovery for neurological disease

Berger, Joseph R., Choi, Dennis, Kaminski, Henry J., Gordon, Mark F., Hurko, Orest, D'Cruz, O'Neill, Pleasure, Samuel J., Feldman, Eva L.

Journal:

Annals of Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 194 KB

english, 2013

40

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

Shen, S., Lang, B., Nakamoto, C., Zhang, F., Pu, J., Kuan, S.-L., Chatzi, C., He, S., Mackie, I., Brandon, N. J., Marquis, K. L., Day, M., Hurko, O., McCaig, C. D., Riedel, G., St Clair, D.

Journal:

Journal of Neuroscience

Année:

2008

Langue:

english

Fichier:

PDF, 853 KB

english, 2008

41

Aminoff's Neurology and General Medicine || The Skin and Neurologic Disease

Année:

2014

Langue:

english

Fichier:

PDF, 8.38 MB

english, 2014

42

The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity

Filiptsova, O.V., Timoshyna, I.A., Kobets, Yu. N., Kobets, M.N., Burlaka, I.S., Hurko, I.A.

Journal:

Egyptian Journal of Medical Human Genetics

Année:

2015

Langue:

english

Fichier:

PDF, 465 KB

english, 2015

43

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

Chomyn, A., Martinuzzi, A., Yoneda, M., Daga, A., Hurko, O., Johns, D., Lai, S. T., Nonaka, I., Angelini, C., Attardi, G.

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1992

44

Pharmacologic Interventions for Stroke: Looking Beyond the Thrombolysis Time Window Into the Penumbra With Biomarkers, Not a Stopwatch

Chavez, J. C., Hurko, O., Barone, F. C., Feuerstein, G. Z.

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 579 KB

english, 2009

45

Neurology and the skin

Hurko, O., Provost, T. T

Journal:

Journal of Neurology Neurosurgery & Psychiatry

Année:

1999

Langue:

english

Fichier:

PDF, 311 KB

english, 1999

46

Heteroplasmy in Chronic External Ophthalmoplegia: Clinical and Molecular Observations

Hurko, Orest, Johns, Donald R, Rutledge, S Lane, Stine, O Colin, Peterson, Patti L, Miller, Neil R, Martens, Margaret E, Drachman, Daniel B, Brown, Robert H, Lee, C P

Journal:

Pediatric Research

Année:

1990

Langue:

english

Fichier:

PDF, 6.22 MB

english, 1990

47

Familial intradural arachnoid cysts

Aarabi, Bizhan, Pasternak, Gavril, Hurko, Orest, Long, Donlin M.

Journal:

Journal of Neurosurgery

Année:

1979

Langue:

english

Fichier:

PDF, 1.58 MB

english, 1979

48

Craniocervical decompression for cervicomedullary compression in pediatric patients with achondroplasia

Aryanpur, John, Hurko, Orest, Francomano, Clair, Wang, Henry, Carson, Benjamin

Journal:

Journal of Neurosurgery

Année:

1990

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1990

49

MELAS Mutation in mtDNA Binding Site for Transcription Termination Factor Causes Defects in Protein Synthesis and in Respiration but no Change in Levels of Upstream and Downstream Mature Transcripts

A. Chomyn, A. Martinuzzi, M. Yoneda, A. Daga, O. Hurko, D. Johns, S. T. Lai, I. Nonaka, C. Angelini and G. Attardi

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1.12 MB

english, 1992

50

Adenylate Cyclase Activity in Bovine Adrenal Medulla 1

HURKO, OREST, ELSTER, PAULA, WURTMAN, RICHARD

Journal:

Année:

1974

Langue:

english

Fichier:

PDF, 308 KB

english, 1974